Mitoribosome assembly comes into view
نویسندگان
چکیده
The folding of ribosomal RNAs is central to the biogenesis mitoribosome and a complex, stepwise process. Five recent cryo-EM studies detail late steps maturation human mitoribosomal large subunit RNA that forms catalytic core ribosome: peptidyl transferase center (PTC).
منابع مشابه
Elusive Pentaquark Comes into View
The proton is made from three quarks, and mesons are made from a quark and antiquark. But what other configurations of quarks and antiquarks can form a particle? From a theoretical standpoint, this question is difficult to answer. Yet new particles with different combinations of quarks keep popping up in experiments. The latest of these, reported by the Large Hadron Collider Beauty (LHCb) Colla...
متن کاملThe 1918 influenza virus: A killer comes into view.
In the fall and winter of 1918–1919, an influenza pandemic of unprecedented virulence swept the globe leaving 40 million or more dead in its wake. The virus responsible for this catastrophe was not isolated at the time, and it seemed that this very lethal infectious agent was lost for study. However, it has recently become possible to study the genetic features of the 1918 “Spanish” influenza v...
متن کاملDecapper comes into focus.
In this issue of Structure, Scarsdale et al. (2006) report structures of the Xenopus X29 Nudix decapping protein, including homodimer structures in complex with cap nucleotides. These structures reveal insights into the mechanism of cap substrate recognition and predict an RNA binding path on the protein surface. The small nucleolar RNAs (snoRNAs) are a group of non-coding RNAs that associate w...
متن کاملAs functional nuclear actin comes into view, is it globular, filamentous, or both?
The idea that actin may have an important function in the nucleus has undergone a rapid transition from one greeted with skepticism to a now rapidly advancing research field. Actin has now been implicated in transcription by all three RNA polymerases, but the structural form it adopts in these processes remains unclear. Recently, a claim was made that monomeric nuclear actin plays a role in sig...
متن کاملA novel site comes into sight
Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2021
ISSN: ['1545-9985', '2331-365X', '1545-9993', '1072-8368']
DOI: https://doi.org/10.1038/s41594-021-00640-3